This medication is an anti-itch medication that contains mixture of zinc oxide (ZnO) with about 0.5% iron (III) oxide, prescribed for itching skin conditions. This medication in some cases is used as a mild antiseptic to arrest infections caused by scratching the affected area. Calamine is proved to be an effective medication in acne treatment. If you have an allergy to caffeine or any other part of this drug. – Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.